Your genetic makeup may be causing your smelly urine. Certain genetic disorders can cause an abnormal smell of the urine, including trimethylaminuria, a metabolic condition that causes foul body odor regardless of hygiene. The urine of people with this condition can take on a fishy or sour smell, affecting not only the urine but also the sweat and breathing. For women, the smell often worsens around menstruation.

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