Leigh's disease is a rare neurological disorder characterized by progressive degeneration of motor and mental abilities. This degeneration is due to a decrease in energy available within the body’s cells, although experts still do not fully understand the specific triggering mechanism. What is certain is that in people with Leigh's disease, body systems eventually degenerate to the point of shutdown. In certain instances, this deadly disease appears in adults, but most cases begin during infancy, usually following exposure to a virus.


1. Genetic Causes of Leigh's Disease

Leigh's disease affects approximately one in every 40,000 newborns. For the disease to present itself, one of at least 26 identified genetic mutations must be present in one of more than 75 genes. These mutations mostly affect a cell’s metabolic features and how they convert energy; they also disrupt the functions of various protein complexes.

Leighs disease

More on Facty Health


This site offers information designed for educational purposes only. You should not rely on any information on this site as a substitute for professional medical advice, diagnosis, treatment, or as a substitute for, professional counseling care, advice, diagnosis, or treatment. If you have any concerns or questions about your health, you should always consult with a physician or other healthcare professional.