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13. Risk Factor: Excess Weight

Studies conclude that obesity is a major risk factor for gallstone-related disorders. Similar to oral estrogens, too much weight increases the amount of cholesterol in bile, leading to gallstone formation. People with obesity also tend to have enlarged gallbladders that do not function properly. Rapid weight loss isn't the best approach to lowering the risk of gallstones, though, as quickly losing weight causes the liver to release more cholesterol and may affect how the gallbladder empties. Weight-loss surgeries and weight cycling also increase the odds of a gallstone attack. For people who are overweight, doctors recommend losing five to ten percent of their starting weight over a six-month period to reduce the risk of gallstone issues.

Overweight man South_agency / Getty Images

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