Unlike iron, calcium doesn’t pair well with other minerals or vitamins. Both magnesium and zinc have negative effects on the absorption of calcium. In contrast, vitamin D tends to increase the bioavailability of calcium. Bioavailability is the proportion of the mineral that can enter circulation. The higher a mineral or drug’s bioavailability, the greater an effect the substance will have. If there are large quantities of calcium in the body, much of it diffuses across the small intestine. Vitamin D improves the chance that bone tissue will absorb calcium, as intended, instead.
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