Duodenal ulcers do not cause a change of appetite directly, but weight issues can be a side effect of the condition. Weight gain can happen if you find yourself eating more often than normal as a result of food easing the pain. Food coats the ulcer with a protective lining, so it feels less sore. Unfortunately, once the food is digested, the pain returns and eating again can be an easy way to alleviate the symptom. If you're experiencing stomach pain that stops after you have eaten and notice you have gained weight, speak to your doctor. He or she may prescribe antacids as a treatment.
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