Many people use a class of medication called angiotensin-converting-enzyme of ACE inhibitors to control blood pressure. Taking ACE inhibitors, particularly after the first trimester, is known to cause significant harm to the fetus. These drugs reduce the amniotic fluid surrounding the baby. As a result, problems in the lungs, kidneys, or skull can develop, and in some cases, can lead to stillbirth. While some experts believe these medications are safe during the first trimester, there is evidence that even at that early stage, antihypertensive drugs should be avoided.
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