3. X-Linked Recessive Inheritance

Alport syndrome may occur as a result of X-linked recessive inheritance of a single mutated COL4A5 gene. In this inheritance pattern, the mutated gene occurs in the X chromosome. It is uncommon for females, who have two X chromosomes, to have a mutated copy of the COL4A5 gene in both. The unaffected X chromosome typically prevents the development of the more acute symptoms of the Alport syndrome. Males who have inherited the mutated gene have just one X chromosome, however, and experience symptoms more acutely.

x-linked mutation alport chromosome ustas7777777 / Getty Images
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