Familial adenomatous polyposis (FAP) is a genetic disease that causes colorectal cancer. In people with this gene mutation, thousands of non-cancerous polyps develop in the colon and rectum and eventually become malignant or cancerous. FAP cannot be cured, but surgical removal of the colon reduces the risk of colorectal cancer.
There are three variations of familial adenomatous polyposis: classic, attenuated, and autosomal. In attenuated FAP, polyp growth begins later in life and colorectal cancer typically does not occur until a person is in their fifties. Autosomal FAP is a more mild form causing significantly fewer polyps.
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