A thickening of the oral tissue inside the mouth is also a sign of oral cancer. A general enlargement of the soft tissue, as well as localized thick sections, may even feel different in texture to the unaffected areas of the mouth. This symptom may also cause pain and difficulty closing the mouth completely. You may experience this thickening on any of the soft tissue areas of the mouth, cheek, back of the throat, palate, and tongue and the only indication from the outside is a slight swell of the face.
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