The kidneys are responsible for how the body processes waste, including calcium. They also filter blood. Because of that, kidney disease is the main risk factor for calciphylaxis. Dialysis and kidney transplants increase this risk. Other diseases also increase the risk of this secondary disease, including inflammatory diseases like rheumatoid arthritis, hyperparathyroidism, and ulcerative colitis. Autoimmune disease, metastatic cancer, and diabetes can also increase the likelihood of developing calciphylaxis.
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