Isthmic spondylolisthesis is caused by another common spine problem, spondylolysis. This similar-sounding condition occurs when stress fractures appear in the vertebrae at the small, thin portion that connects the facet joints — the part of the spine that allows for bending and twisting. These cracks weaken the bone, which can lead to it slipping out of place. The most common site is the fifth vertebra in the lumbar spine.
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