The enzyme glutamic acid decarboxylase synthesizes GABA from glutamine. It is inhibitory, so when it interacts with a neuron, the neuron is less likely to release neurotransmitters. GABA interacts with ionotropic GABAa and metabotropic GABA receptors. The former interact with a negatively charged chlorine ion that flows to the neuron, while metabotropic receptors interact with a positive potassium ion that flows out of the neuron. Proteins then transport GABA into glial cells, where it is degraded by enzymes.
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