2. Peripheral Nervous System

In the peripheral nervous system, endorphins work by binding to opioid receptors located throughout the peripheral nerves. When endorphins bind to these receptors, the connection blocks the release of substance P, a small peptide that contributes to the pain response by transmitting pain signals from the sensory nerves to the central nervous system. As a result, feelings of pain are reduced.

peripheral nervous system Peter Dazeley / Getty Images


This site offers information designed for educational purposes only. You should not rely on any information on this site as a substitute for professional medical advice, diagnosis, treatment, or as a substitute for, professional counseling care, advice, diagnosis, or treatment. If you have any concerns or questions about your health, you should always consult with a physician or other healthcare professional.