2. Peripheral Nervous System

In the peripheral nervous system, endorphins work by binding to opioid receptors located throughout the peripheral nerves. When endorphins bind to these receptors, the connection blocks the release of substance P, a small peptide that contributes to the pain response by transmitting pain signals from the sensory nerves to the central nervous system. As a result, feelings of pain are reduced.

peripheral nervous system Peter Dazeley / Getty Images
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