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2. Mast Cells

Many immune cells can create histamine, but the most prominent source is mast cells, which exist throughout the body’s connective tissues, performing many important functions. Each mast cell has surface receptors that bind to immunoglobulin E. When an antigen crosslinks immunoglobulin E on the mast cell surface, the cell begins to secrete histamine and other mediators.

mast cell histamine luismmolina / Getty Images
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