Erythema Multiforme Major, or EM Major, is severe and potentially life-threatening. It differs from EM Minor in that it covers more of the body, including mucous membranes. The condition also causes epidermal detachment. This means that you could potentially lose skin in the affected areas, causing sepsis or even death. EM Major is connected to other diseases such as Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis.
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