Grover's disease — also called transient acantholytic dermatosis or persistent acantholytic dermatosis — is a rare skin disorder that disproportionately affects men over 50. Experts do not fully understand the cause of the disease, but a variety of factors may contribute to and exacerbate it. Grover's disease presents as a skin rash with distinct characteristics, though diagnosis can be difficult as the symptoms are similar to those of other skin conditions.
Grover's disease is benign, and the skin rash often develops on the trunk and back. The red rash appears as a papulovesicular eruption, meaning it has solid, reddened elevations and small- to medium-sized transparent, fluid-filled vesicles.
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