2. Chronic Inflammation of the Bile Ducts

In primary sclerosing cholangitis, inflammation leads to scarring and narrowing of the bile ducts. In repairing the damage caused by inflammation, fibrous connective tissue or scar tissue forms on the walls of the ducts. The build-up of this scar tissue can eventually block the ducts and cause deterioration.

primary sclerosing cholangitis inflammation scarring mr.suphachai praserdumrongchai / Getty Images

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