Erythema nodosum usually presents as reddish, painful, tender lumps about the size of a dime or quarter, situated on the front of the legs, below the knees. The inflammation may come and go for weeks. Low-grade fever and unexplained exhaustion are also signs of erythema nodosum. As the lumps shrink, they may leave a bruised appearance. In rare cases, lesions develop on the palms and soles of the feet. In children, these lesions can sometimes be seen on the knees, ankles, extensor aspects of arms, face, neck, thighs, and trunk.
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