In early stages, patients may experience tingling in their toes and fingertips. This tingling may even start to feel like burning. They may experience numbness and tingle even during minimal exercise. There are many possible causes of numbness and tingling. Some of these are pressure on a nerve or use of certain medicines.

Any supportive care at this stage is to try and maximize blood flow to the area. Treatment of these symptoms will depend on the cause. As numbness leads to a decrease in feeling, a patient may be more likely to suffer accidental injury. Protection from bruises, cuts, burns, and other injuries is important. 

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