At first, bilirubin is unconjugated, meaning it does not bind to chemicals in the body. It is not water soluble in this state due to the bond with albumin that enables it to travel through the body to the liver. In the liver, an enzyme called glucuronyltransferase changes the bilirubin into a conjugated (binding) state by removing the albumin, and the bilirubin becomes a component of bile. Bilirubin must be conjugated to be expelled from the body.
Receive updates on the latest news and alerts straight to your inbox.
This site offers information designed for educational purposes only. You should not rely on any information on this site as a substitute for professional medical advice, diagnosis, treatment, or as a substitute for, professional counseling care, advice, diagnosis, or treatment. If you have any concerns or questions about your health, you should always consult with a physician or other healthcare professional.