Bacteria are living organisms that multiply and want to survive. When a drug is used to kill them off, sometimes a select few survive. The "stronger" bacteria then multiply, increasing the amount of drug-resistant microbes.
Misuse of antibiotics, such as not finishing a course of prescribed antibiotics or taking antibiotics when they are not needed, is the "single leading factor" of the superbug problem. When a course of antibiotics is not complete, the stronger remaining microbes multiply. Eventually, there will be no medication to treat them.
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