One of the first signs of smallpox is a high fever. Typically, this will occur about two weeks after you contract smallpox. Prior to developing a fever, you are not contagious and will not feel ill. Once the virus has completed its initial incubation period, you will experience flu-like symptoms including a fever. Although it might not seem alarming at first, anyone who experiences a fever and then develops a rash should immediately contact their physician. In most cases, the fever will decline as the rash begins to form, then peak after the rash turns into blisters.
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