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16. Toledo, Ohio

This major port city is among the top five busiest for the Great Lakes. When compared to cities of similar size, Toledo has a lot of crime. In fact, it has more overall crime than 96% of the other cities in Ohio. The CDC ranked the city as the 10th most dangerous for drug overdoses. Methamphetamines, heroin, and other drugs are easily available. Alcohol abuse is also a significant problem, adding more deterrents to a happy life.

  • Unemployment Rate: 13.70%
  • Divorce Rate: 14.9%
  • Three-Year Change in Earnings Per Individual: 0.42%
  • Well-Being Index Score: 59.80
  • Poor Mental Health Days: 4.20
  • Misery Score: 82.4

The Saddest, Unhappiest Cities in America Mshake / Getty Images

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