What are the Potential Complications of Gout?

13. Sleep Disruption

Research has observed an inverse relationship between serum uric acid concentrations and sleep duration. Some studies suggest that inadequate sleep might trigger metabolic pathways that increase the production of purines and uric acid. In turn, elevated uric acid levels promote systemic inflammation. However, there is evidence that chronic inflammation may lead to insomnia.

Gout-induced sleep disturbances commonly arise from pain or the inability to find a comfortable resting position. Medication side effects and chronic joint pain or swelling also impede rest. Many people with gout have to make frequent trips to the bathroom during the night, as well.