Because melanoma cells make melanin, the tumors are usually dark in color, though they can also be pink, tan, or white, which are not as noticeable. Melanomas can appear anywhere on the skin but are likely to start on the legs in women and the chest or back in men. People with darkly pigmented skin have a lower risk of melanoma, though it is still possible on the soles of the feet, palms of the hands, and under the fingernails. Besides UV exposure, other risk factors for melanoma include having many moles, older age, family history of melanoma, and a weak immune system. Skin exposed to the sun is not the only place melanoma can develop. Look out for suspicious moles that change in color or size or that start bleeding. Moles with irregular borders, different colors, or are painful or itch should be checked as well.

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